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About the Department of Neuroscience
The Department of Neuroscience is located within the university's Kenneth P. Dietrich School of Arts and Sciences. The department, established in 1986 as an expansion of the program inbehavioral neuroscience, was founded on the notion that neuroscience was an up and coming discipline that belonged as an undergraduate major and a field of graduate study.
The Undergraduate Program attracts a relatively large and academically successful group of majors, the great majority of whom go on to medical or graduate school. The faculty and graduate students form a substantial component of the campus-wide Center for Neuroscience at the University of Pittsburgh (CNUP), an organization that serves the entire community of neuroscientists at this institution.
Our Dietrich School faculty are a distinguished group of scientific investigators; they are very productive in the laboratory, and they have received numerous grants and awards for their research. Also distinctive are the collegial interactions that occur among the faculty members, which provide new ideas and approaches to their research programs. The total number of faculty members with primary tenure-stream appointments is 13, and faculty size has been increased to approximately 25 by the addition of faculty members with a primary departmental appointment outside the tenure stream and faculty members with secondary appointments whose primary appointments are elsewhere on campus or at neighboring Carnegie Mellon University.
Our doctoral training program in the CNUP is thriving. We draw from a large pool of excellent applicants, and our students develop first-rate academic and research skills as they progress towards a PhD degree. Our small Masters Degree program is also thriving and our undergraduate program similarly is excellent. Our courses are well taught and demanding, and each year we attract a sizable group of outstanding students despite the fact that students with interests in the biomedical sciences typically do not enter college aware of neuroscience as a discipline. A remarkable number of these undergraduate students participate actively in the laboratory research programs of our faculty. Thus, the Department's faculty represent a group of dedicated instructors and mentors as well as scientists.
The major strengths of the Department of Neuroscience are its personnel—faculty, graduate students, research associates, and staff—and their commitment to excellence in teaching, training, and research. There is in the department a strong sense of respect for one another's talents, accomplishments, and personal integrity, a sense of communal mission with regard to our aspirations and goals in research and teaching, and a sense of confidence that we know what has to be done and can do it.
The Department has become successful and prominent based on the determination, energy, imagination, and skills of its faculty as investigators and as mentors, and on the support of the institution and the funding agencies. Consequently, morale is high and so is our optimism that we will continue to develop and maintain a world-class department.
University of Pittsburgh
Kenneth P. Dietrich School of Arts and Sciences
Department of Neuroscience
A210 Langley Hall
Pittsburgh, PA 15260
412.624-5043
412.624-9198 FAX
Upcoming Seminars and Events
For a complete list of seminars please visit the CNUP Website.
Department of Neuroscience Seminar:
Ph.D. Dissertation Defesnse:
Monday, June 3, 2013
10:00 a.m.
Gil D. Hoftman
Center for Neuroscience
Kenneth P. Dietrich School of Arts & Sciences/Neuroscience
Seminar Title: Development of Cortical GABA Circuitry: Identifying Periods of Vulnerability to Schizophrenia
Location: 2nd Floor Auditorium, LRDC
Sponsor: Kenneth P. Dietrich School of Arts and Sciences, Department of Neuroscience
Department of Neuroscience Seminar:
Monday, June 3, 2013
4:00 p.m.
Pat Levitt, Ph.D.
Provost, Professor, and Director
Zilkha Neurogenetic Institute and Chair
Department of Cell & Neurobiology
Keck School of Medicine
University of Southern California
Seminar Title: The Neurobiology of Social Behavior Development
Location: 2nd Floor Auditorium, LRDC
Sponsor: Kenneth P. Dietrich School of Arts and Sciences, Department of Neuroscience
Recent Faculty Publications
Leathers, M. L. and C. R. Olson. Response to comment on “In monkeys making value-based decisions, LIP neurons encode cue salience and not action value”.
Science, 340(6131): 430, 2013
Winters, D.B., Kruger, J.M., Huang, X., Gallaher, Z.R., Ishikawa, M., Czaja, K., Krueger, J.M., Huang, Y.H., Schluter, O.M., Dong, Y. CB1-expressing neurons in the nucleus accumbens
PNAS USA 109(40): E2717-2725 (2012)
Suska, A., Lee, B.R., Huang, Y.H., Dong, Y., Schluter, O.M. Presynaptic enhancement of glutamatergic transmission within the nucleus accumbens following cocaine exposure
PNAS USA 110(2):713-718 (2013)
Otaka, M., Ishikawa, M., Lee, B.R., Liu, L., Neumann, P.A., Cui, R., Huang, Y.H., Schluter, O.M., Dong, Y. Exposure to cocaine regulates inhibitory synaptic transmission in the nucleus accumbens
Journal of Neuroscience. Featured Article. 33(16): 6753-6758
Ishikawa, M., Otaka, M., Huang, Y.H., Neumann, P.A., Winters, B.D., Grace, A.A., Schluter, O.M., Dong, Y. Dopamine triggers heterosynaptic plasticity
Journal of Neuroscience. 33(16): 6759-6765
Card, J.P., Kobiler, O., McCambridge, J., Ebdlahad, S., Raizada, M.K., Sved, A.F., Enquist, L.W. Microdissection of neural networks by conditional reporter expression from a Brainbow Herpesvirus
PNAS USA 108: 3377-3382, (2011)
This manuscript reports upon the development of novel technology for defining neural circuits linked to neurochemically defined populations of neurons.
Card, J.P., Kobiler, O., Ludmir, E.B., Desai, V., Sved, A.F., Enquist, L.W. A dual infection pseudorabies virus conditional reporter approach to identify projections to collateralized neurons in complex neural circuits
PLOS One 6:1-12,2011.
This manuscript reports the development of novel technology to define populations of neurons that are synaptically linked to circuits linked to separate targets
Agassandia, K., Shan, Z., Raizada, M., Sved, A.F., Card, J.P. C1 Catecholamine neurons form local circuit connections within the rostroventrolateral medulla of rat
Neuroscience 227:247-259, 2012
This paper provides support for the hypothesis that local circuit connections among projection specific populations of neurons in the rat brainstem coordinate activity within a distributed neural network that controls cardiovascular function.
Tarr, T.B., Dittrich, M., Meriney, S.D. Are unreliable release mechanisms conserved from NMJ to CNS?
Trends in Neuroscience 36 14-22
Tarr, T.B., Valdomir, G., Liang, M., Wipf, P., Meriney, S.D. New calcium channel agonists as potential therapeutics in LEMS and other neuromuscular diseases.
Annals New York Academy of Sciences, (2012) 1275: 85-91
Cai, L., Bakalli, H., and Rinaman, L. Yohimbine anxiogenesis in the elevated plus maze is disrupted by bilaterally disconnecting the bed nucleus of the stria terminalis from the central nucleus of the amygdala.
Neuroscience, 223 (2012) 200-208.
The anxiogeneic effects of increased noradrenergic signaling in rats require direct CEA-algBST interactions that do not alter anxiety-like behavior under baseline conditions
Bienkowski, M. and Rinaman, L. Common and distinct neural inputs to the medial central nucleus of the amygdala and the anterior ventrolateral bed nucleus of stria terminalis in rats.
Brain Structure and Function 218 (2013) 187-208.
Neural tract tracing demonstrates similarities and differences in inputs to CEAm and BSTvl that provide new anatomical insights into the functional organization of these limbic forebrain regions
Zheng H. and Rinaman, L. Yohimbine anxiogenesis in the elevated plus maze requires hindbrain noradrenergic neurons that target the anterior ventrolateral bed nucleus of the stria terminalis.
European Journal of Neuroscience (2013) In press. doi: 10.1111/ejn.12123 [Epub ahead of print]
The anxiogenic effects of increased neurodrenergic signaling in rats are mediated by inputs from hindbrain noradrenergic neurons, and not by inputs from the pntine locus coeruleus.
Maniscalco, J.W. and Rinaman, L. Overnight food deprivation markedly attenuates hindbrain noradrenergic, glucagon-like peptide-1, and hypothalamic neural responses to exogenous cholecystokinin in rats.
Physiology & Behavior (2013) In press.
Activation of neurodrenergic A2, GLP-1, and medial parvocellular PVN neurons is significantly modulated by feeding status in rats, suggesting a mechanism through which food intake and metabolic state might impact hypothalamic neuroendocrine responses to homeostatic challenge.
Maniscalco, J.W., Kreisler, A.D., and Rinaman, L. Satiation and stress-induced hypophagia: examining the role of hindbrain neurons expressing prolactin-releasing peptide (PrRP) or glucagon-like peptide 1 (GLP-1).
Frontiers in Neuroscience 6 (2013) 199. doi: 10.3389/fnins.2012.00199
Hindbrain PrRP and GLP-1 neurons engage hypothalamic and limbic forebrain networks that drive parallel behavioral and endocrine functions related to food intake and homeostatic challenge, and modulate conditioned and motivational aspects of food intake.
Leathers, ML and Olson CR. In monkeys making value-based decisions, LIP neurons encode cue salience and not action value.
Science, 338(6103): 132-35, 2012.
Card, JP, Kobiler O, Ludmir, EB, Desai, V, Sved AF, Enquist, LW., A Dual Infection Pseudorabies Virus Conditional
Reporter Approach to Identify Projections to
Collateralized Neurons in Complex Neural Circuits.,
PLoS One. 2011;6(6):e21141. Epub 2011 Jun 16.